1. 제 목 : Adultneurogenesis:Newhorizonsfornewneurons
2. 연 자 : AmeliaJ.Eisch,Ph.D.
3. 소 속 : TheUniversityofTexasSouthwesternMedical Center, Dallas, Texas, USA
4. 일 시 : 2007년 10월 24일(수) 오후4:00
5. 장 소 : 고려대 의과대학 대학원 제 2강의실
6. 내 용 :
The links between adult hippocampal neurogenesis and psychiatric disorders, such as depression, are intriguing remain unclear. Here we review our attempts to understand the relationship between adult neurogenesis, depression, and stress on multiple levels using cellular, microenvironmental, and behavioral analyses. From a cellular level, we explore the role of proneural basic helix loop helix transcription factors in the regulation of adult neurogenesis seen after manipulations known to be antidepressive, such as antidepressant exposure and voluntary running. From a microenvironmental level, we explore the role of the maverick cyclin dependent kinase, Cdk5, in adult hippocampal neurogenesis. Our major approach, however, is to combine our cellular and microenvironmental analyses with behavioral analyses. For our first project using this combination approach, we inducibly ablate adult neurogenesis by administering tamoxifen to our nestin-CreERT2 mice crossed to floxed-stop DTA mice. Our subsequent behavioral analyses reveal an intriguing relationship between adult neurogenesis, depression and anxiety. For our second project combining cellular, microenvironmental and behavioral approaches, we use the social defeat stress model to identify populations of mice that are behaviorally “resilient” to the stress versus those that are “vulnerable” to the stress. We then explore specific changes in neurogenesis and subgranular zone microenvironment that relate to resilient and vulnerable populations of mice relative to control mice. Taken together, these projects underscore the importance of the timing of behavioral analysis and the role of the microenvironment in determining the relationship between adult hippocampal neurogenesis and depression-related behaviors
7. 문 의 :의과대학 약리학교실 신경호 교수님(920-6195)