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Biomaterials, Volume 24, Issue 6, March 2003, Pages 893-900 | doi:10.1016/S0142-9612(02)00420-9

Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks

Yong Doo Park, Nicola Tirelli, Jeffrey A. Hubbell

Department of Materials, Institute for Biomedical Engineering, Swiss Federal Institute of Technology and University of Zurich, Moussonstrasse 18, CH-8044 Zurich, Switzerland

Received 3 May 2002; Accepted 6 September 2002. Available online 19 December 2002.

Corresponding author : Nicola Tirelli ; Tel.: +41-1-632-63-48; fax: +41-1-632-12-14

Hyaluronic acid (HA) was derivatized with methacrylic esters used for the preparation of hydrogels via photopolymerization. Poly(ethylene glycol) diacrylate (PEG-DA) with a molecular weight of 570 was also used as a comacromonomer to improve elastic modulus and swelling behavior. The hydrogels were readily degraded by hyaluronidase and their mechanical properties could be modulated by HA molecular weight and concentration of PEG-DA. The incorporation of RGD peptides allowed modulation of the HA properties from cell non-adhesive to adhesive. Human dermal fibroblasts were cultured on the RGD, RDG, and non-functionalized HA hydrogels for up to 7 d, showing adhesion and proliferation only with incorporated RGD.

Keywords: Hyaluronic acid; Hydrogels; Photopolymerization; RGD; Cell adhesion